Study: CBDA and CBGA help prevent COVID

Study from Oregon State University shows thst several cannabinoids in Hemp could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. 

Analysis of over 93,000 patients tested for COVID at University of Chicago Medical Center showed an 88% reduction in infection rates among those specifically reporting CBD use in their medical records.

Hemp and COVID are in the news, and this time it may be different.

If you are like me, you are tired of COVID... it has been a long haul.  I'm tired of the politicization of our health, tired of conspiracy theories, tired of miracle cures, tired of CBD hand sanitizer, and definitely tired of seeing people get sick.

It appears COVID-19 is here to stay, and we need to start learning how to live with it.  What that "new normal" will (or should) look like is going to generate a lot of debate, posturing, and even more politicization... We are going to stay out of it, keep doing what we do, and take charge of our own health.

 

The COVID warriors: Cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA).

In light of a recent piece of research out of Oregon State University, we have yet another reason to include hemp in our daily health routines.  Researchers at OSU have found evidence that several cannabinoids contained in hemp extract prevent COVID-19 spike proteins from infecting epithelial cells.  The two cannabinoids with the highest affinity for the spike proteins were cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA).

According to OSU's Dr. van Breeman:

"Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle.  That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.”

You can read the entire study (Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants) on the National Institute of Health's PubMed database.

Because the research was conducted using early variants, and in an in vitro study, there still seems to be a a lot of unanswered questions.  It is hard to not to get excited though, when you find out that what you are already doing could be keeping you healthy in ways you didn't expect.  Study: CBD use reduced COVID infection rates by 88% 

It is especially exciting in light of an earlier University of Chicago paper (Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response) that indicated cannabidiol (CBD) in epithelial lung cells "acts after cellular infection, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription."  Evidence was also presented that "CBD effectively reverses viral induction of cytokines that can lead to the deadly cytokine storm at later stages of infection." 

Interestingly, the researchers noted that the the effects of CBD were "significantly repressed" by combining with THC at a 1:1 ratio because of competitive receptor binding.  

This study also looked beyond the laboratory and confirmed their results in the general population.  Analysis of over 93,000 patients tested for COVID at University of Chicago Medical Center showed a 29% reduction in infection rates among those reporting non-CBD cannabinoid use, and an even greater reduction (88%) in those specifically reporting CBD use in their medical records.

 

 

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